P743 Relative association of bowel urgency improvement versus remission of stool frequency and rectal bleeding with Patient Global Rating of Severity or Change scores in moderately-to-severely active Ulcerative Colitis: An analysis from the LUCENT-1 and LUCENT-2 Phase 3 trials

Abstract Background Bowel urgency is a common and disruptive symptom of ulcerative colitis (UC), distinct from stool frequency (SF) rectal bleeding (RB).1 Information limited on the relationships between bowel clinically meaningful improvement (CMI), remission, SF remission or RB in Patient Global Rating Severity Change (PGRS/PGRC) scores patients with moderately-to-severely active UC. We estimated associations CMI PGRS/PGRC while adjusting for potential confounding effects using data LUCENT-1 (NCT03518086) LUCENT-2 (NCT03524092) phase 3 trials. Methods severity was assessed by Urgency Numeric Scale (NRS; 0=no to 10=worst possible urgency).2 The 6-point PGRS scale (1=none 6=very severe) recorded an electronic daily diary, weekly were averaged. 7-point PGRC (1=very much better 7=very worse) at week (W) 12 W52.3 Other outcomes included: (Urgency NRS score=0 1), (≥3-point decrease score baseline), (Modified Mayo subscore=0 1 ≥1 point baseline) subscore=0).2 Mediation analyses performed separately examine relative association direct (predictors) (mediators). Analyses treatmentagnostic combined mirikizumab placebo groups (N=1162) (N=544) trials W12 40 (W52 study). Results At W12, improvements primarily due (63.5%, 56.3%), (21.0%, 21.6%) (15.5%, 22.1%; Fig.1A). Similar results observed (Fig.1B). W52, accounted 54.7% 79.1% (Fig.2A). CMI, are shown Fig. 2B. Conclusion Improvements remission. These support that may influence patients’ perceptions disease change activity References: 1Dubinsky MC, et al. J Crohns Colitis. 2020;14(1):S200. 2Dubinsky Rep Outcomes. 2022;6(1):114. 3Rubin DT, Gastroenterology. 2022;162(3):S14-5.